Institute of Physiology and Biochemistry “Ivan Đaja”
Faculty of Biology
University of Belgrade
EVs are known to be involved in intercellular communication, as well as to play a role in diseases of the central nervous system. Depending on their content, they may be involved in maintaining homeostasis, but may promote neuroinflammation and the progression of neurodegeneration. On the other hand, in our earlier research we showed that the serum fraction of immunoglobulin G (IgG) from patients with amyotrophic lateral sclerosis (ALS, a motor neuron disease) causes a calcium response and a change in the mobility of acidic vesicles in astrocytes and oxidative stress in microglia in vitro. The aim of our research is to investigate how ALS IgG affect the release and content of EVs by glial cells in vitro and possible implications in the pathogenesis of the disease.
Prof. Dr. Pavle Anđus